洛伐他汀合成酶调控基因lovE和mkH的克隆及其序列分析比较(7)

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　　［10］ KENNEDY J, AUCLAIR K, KENDREW S G, et al. Modulation of polyketides synthase activity by accessory proteins during lovastatin biosynthesis［J］. Science,1999, 284(5418): 1368-1372.

　　［11］ SUTHERLAND A, AUCLAIR K, VEDERAS J C. Recent advances in the biosynthetic studies of lovastatin ［R］. Curr Opin Drug Discov Devel, 2001, 4(2): 229-236.

　　［12］ TODD R B, ANDRIANOPOULOS A. Evolution of a fungal regulatory gene family: The Zn(II)2Cys6 binuclear cluster DNA binding motif［J］. Fungal Genet Biol, 1997, 21(3): 388-405.

　　［13］ CHEN Y P, TSENG C P, LIAW L L, et al. Cloning and characterization of monacolin K biosynthetic gene cluster from Monascus pilosus［J］. Agriculture and Food Chemistry, 2008, 56(14):5639-5646.

　　［14］ HUTCHINSON C R, KENNEDY J, PARK C, et al. Aspects of the biosynthesis of nonaromatic fungal polyketides by iterative polyketide synthases［J］. Antonie Van Leeuwenhoek, 2000, 78, 287-295.

　　［15］诸葛健, 王正祥. 工业微生物实验技术手册［M］. 北京: 中国轻工业出版社, 1994: 109-112.

　　［16］ PARK C, HUTCHINSON C R, KENNEDY J. Method of producing antihypercholesterolemic agents ［P］. US Patent, 2004033570, 2004-02-19.

L, PISANTI S, et al. Lovastatin induces apoptosis of krastransformed thyroid cells via inhibition of ras farnesylation and by modulating redox state［J］. J Mol Med, 2008, 86(12):1341-1351.

　　［8］ YU X, LUO Y, ZHOU Y, et al. BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1CDK4p21WAF1/CIP1 pathway: analyses using a breast cancer cell line and tumoral xenograft model［J］. Int J Oncol, 2008, 33(3):555-563.

　　［9］ HENDRISKSON L, DAVIS C R, ROACH C, et al. Lovastatin biosynthesis in Aspergillus terrus: characterization of blocked mutants, enzyme activities and a mulifunctional polyketide synthase gene［J］. Chem Biol, 1999, 6(7): 429439.

　　［10］ KENNEDY J, AUCLAIR K, KENDREW S G, et al. Modulation of polyketides synthase activity by accessory proteins during lovastatin biosynthesis［J］. Science,1999, 284(5418): 1368-1372.

　　［11］ SUTHERLAND A, AUCLAIR K, VEDERAS J C. Recent advances in the biosynthetic studies of lovastatin ［R］. Curr Opin Drug Discov Devel, 2001, 4(2): 229-236.

　　［12］ TODD R B, ANDRIANOPOULOS A. Evolution of a fungal regulatory gene family: The Zn(II)2Cys6 binuclear cluster DNA binding motif［J］. Fungal Genet Biol, 1997, 21(3): 388-405.

　　［13］ CHEN Y P, TSENG C P, LIAW L L, et al. Cloning and characterization of monacolin K biosynthetic gene cluster from Monascus pilosus［J］. Agriculture and Food Chemistry, 2008, 56(14):5639-5646.

　　［14］ HUTCHINSON C R, KENNEDY J, PARK C, et al. Aspects of the biosynthesis of nonaromatic fungal polyketides by iterative polyketide synthases［J］. Antonie Van Leeuwenhoek, 2000, 78, 287-295.

　　［15］诸葛健, 王正祥. 工业微生物实验技术手册［M］. 北京: 中国轻工业出版社, 1994: 109-112.

　　［16］ PARK C, HUTCHINSON C R, KENNEDY J. Method of producing antihypercholesterolemic agents ［P］. US Patent, 2004033570, 2004-02-19.

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